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Understanding Cognitive and Developmental Neuroscience of Suicide and Non-suicidal Self-injury

  • Project leaders:

    • Chang Lei & Xue Wen

  • Overview

    1. Our project is dedicated to investigating the cognitive and developmental neuroscience aspects of suicide and non-suicidal self-injury (NSSI). Through advanced techniques such as MRI and EEG, we prioritize the examination of neural predictors and mechanisms of pain and interoception in individuals who engage in suicide and NSSI. By integrating these diverse research areas, we strive to gain a comprehensive understanding of the complex issues surrounding suicide and NSSI, aiming to contribute to the development of effective interventions and strategies that improve mental health outcomes for at-risk individuals while promoting overall well-being and preventing self-destructive behaviors among young populations.

    2. Simultaneously, we utilize the Adolescent Behavioral and Cognitive Development (ABCD) database to explore various related aspects. Specifically, we delve into the intergenerational transmission of suicide and its relationship with brain development in children and adolescents. Moreover, we investigate the impact of school bullying on NSSI, suicide, and brain development among young individuals. Additionally, we focus on examining the neurobiological mechanisms involved in the transition of  self-harm behaviors.

    3. Through these comprehensive studies, we aim to shed light on the multifaceted nature of suicide and NSSI, generating valuable insights that can inform the development of effective interventions and strategies. Our ultimate goal is to improve mental health outcomes for individuals at risk while fostering a supportive environment that prevents self-destructive behaviors among young populations.

  • Further reading:

    • Wen, X., Shu, Y., Qu, D., Wang, Y., Cui, Z., Zhang, X., & Chen, R. (2023). Associations of bullying perpetration and peer victimization subtypes with preadolescent’s suicidality, non-suicidal self-injury, neurocognition, and brain development. BMC Medicine, 21(1), 141.

    • Qu, D., Wen, X., Liu, B., Zhang, X., He, Y., Chen, D., Duan, X., Yu, J., Liu, D., & Zhang, X. (2023). Non-suicidal self-injury in Chinese population: A scoping review of prevalence, method, risk factors and preventive interventions. The Lancet Regional Health–Western Pacific.

    • Qu, D., Feng, Y., Wen, X., & Chen, R. (2023). The effect of interoceptive awareness as the underlying mechanism between anxiety and NSSI behaviors. Journal of Affective Disorders Reports, 100598.

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